This week’s newsletter covers California’s landmark hemp THC legislation, new research on how THC and CBD distinctly affect brain connectivity, the immune role of cannabinoid receptors, the therapeutic potential of CBG, CBD’s effects on cognitive function in older adults, chlorophyll’s impact on CBD bioavailability, and a review of psychedelic-associated depersonalization disorder.
Noteworthy Read
California Passes Bill to Ban Intoxicating Hemp Products Outside Cannabis Market (Cannabis Business Times)
California lawmakers have passed Assembly Bill 8, which bans the sale of inhalable hemp-derived cannabinoids (e.g. delta-8, delta-10) in smoke shops, gas stations, and other retail settings, consolidating those products under the regulated cannabis framework.
More Noteworthy Reading
Cannabis Compounds Have Distinct Effects on Brain Connectivity and Blood Flow (PsyPost)
In a rodent study, THC markedly increased functional connectivity and cerebral blood flow across multiple brain regions, while CBD reduced connectivity but left blood flow unchanged.
Deficiency of Cannabinoid Receptors Increase Susceptibility to Bacterial Infection (PubMed)
Research indicates that animals lacking CB1 or CB2 cannabinoid receptors show heightened vulnerability to bacterial infections, suggesting those receptors play a key role in immune defense and pathogen resistance.
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View more in Endocannabinoid System
CBG and CBGA: Exploring the Potential of the “Mother of Cannabinoids” (Nutraceutical Business Review)
This article explores emerging evidence for the therapeutic promise of cannabigerol (CBG) and its acid form (CBGA), including anti-inflammatory, neuroprotective, and anti-cancer properties, along with challenges in sourcing and formulation.
Research Round-Up
Review Study: CBD and Cognitive Function in Older Adults (PubMed)
This systematic review examines existing clinical research on cannabidiol (CBD) use in older adults, finding mixed evidence regarding cognitive benefits or risks and highlighting gaps in study design, dosing, and long-term outcomes.
Study: Chlorophyll Boosts CBD Bioavailability and Therapeutic Effects (Marijuana Review / NewsBreak)
A preliminary study claims that including chlorophyll in CBD formulations may enhance absorption and efficacy by improving solubility and pharmacokinetics.
Psychedelic-Associated Depersonalization Disorder (PubMed)
This paper reviews cases and mechanisms of depersonalization disorder linked to psychedelic use, examining how altered neural circuits, dissociative states, and receptor dynamics may contribute to persistent identity disruption in some users.
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View more in Psychedelics
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