This week’s newsletter covers CBD’s potential as a treatment for a rare mitochondrial disease, ongoing debates around hemp and marijuana regulation, rising concerns about delta-8 THC exposure in children, and new research on the endocannabinoid system’s role in Alzheimer’s disease.
Noteworthy Read
Cannabidiol Alleviates Symptoms of Rare Mitochondrial Disease (LabOnline)
A recent study found that daily cannabidiol (CBD) administration improved symptoms and extended lifespan in animal models of Leigh syndrome, a rare and severe mitochondrial disease. CBD was shown to boost cell function, particularly in muscle and nerve cells, by providing antioxidant and anti-inflammatory effects. The study, which also examined patient-derived cells, revealed that CBD improves mitochondrial function, and these promising results could lead to new treatments for the condition.
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More Noteworthy Reading
Cannabis Industry Report Advocates for ‘Level Playing Field’ Between Hemp & Marijuana (Green Market Report)
A report by the Reason Foundation criticizes current federal laws that separate hemp and marijuana based on an “arbitrary” definition from the 1970s. It highlights how hemp-derived products like delta-8 THC have gained popularity due to fewer restrictions compared to marijuana. The report suggests aligning the regulations for both hemp and marijuana, proposing the removal of cannabis from the Controlled Substances Act and creating a unified regulatory and tax structure. This would allow both industries to operate in a more competitive and balanced market.
Study Finds Sharp Rise in Delta-8 THC Poisonings in Young Kids (Parents.com)
A new study reveals a sharp rise in poison center calls for delta-8 THC exposure in children, with cases increasing nearly 80% from 2021 to 2022. Delta-8 THC, similar to delta-9 THC but less potent, is often marketed in child-attractive forms like gummies or brownies. Many incidents involve accidental ingestion due to enticing packaging. Experts urge parents to store products securely and keep them away from children. Symptoms of ingestion include confusion, vomiting, and sedation, with severe cases requiring emergency care.
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Research Round-Up
CBD Reduces Daytime Fatigue (NORML)
A study from Croatia found that taking CBD for five weeks led to reduced daytime fatigue and improved psychological well-being, according to research published in Cannabis and Cannabinoid Research. Participants who took CBD reported less daytime sleepiness and better vitality, though their overall sleep quality did not improve. This aligns with previous studies suggesting that CBD may help people with sleep issues when taken before bed.
Meta-Analysis: The Endocannabinoid System in Alzheimer’s Disease (PubMed)
This study looked at how the body’s endocannabinoid system (ECS) is different in people with Alzheimer’s disease (AD). It found that people with AD have lower levels of the CB1 receptor in certain brain areas and higher levels of a compound called 2-AG and its enzyme. These changes in the ECS might play a role in the disease, suggesting that targeting the ECS could be a potential way to develop treatments for Alzheimer’s.
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A heartfelt thank you to all of the CBD brands whose generous support empowers Project CBD to shine a light on the latest plant medicine research and bring these important stories to our community.
