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Little needs to be said about the devastating impact methamphetamine abuse can have. It is a highly addictive substance whose use can lead to transient psychotic behavior and long-term cognitive problems.

As part of an Iranian researcher’s PhD thesis, two scientists demonstrate that CBD can reduce the likelihood of methamphetamine relapse, even while one deals with stresses like sleep deprivation. This is particularly important because drug withdrawal often causes temporary insomnia, yet many of the medications that induce sleep are highly addictive. The researchers injected CBD directly into rats’ brain and measured the conditioned place preference for meth – a common preclinical predictor of addiction and relapse – under different experimental conditions. The implications for humans are, of course, speculative as of now.

Read study: Cannabidiol inhibits priming-induced reinstatement of methamphetamine in REM sleep deprived rats


Adrian Devitt-Lee is a research scientist and longtime Project CBD contributor. © Copyright, Project CBD. May not be reprinted without permission.


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